Currently there are numerous tools and activities used to assist countries in the collection of and use of routine tuberculosis (TB) surveillance, costing, and program data. However, implementation of such activities can place an extensive burden on Ministries of Health and implementing partners and may not occur in an efficient manner. With funding from the Bill & Melinda Gates Foundation, the CDC Foundation is working with the Centers for Disease Control and Prevention (CDC) Division of Global HIV and Tuberculosis to conduct a review of globally-endorsed TB data generation and analysis tools. The goal of this project is to document effective and efficient approaches to the use of TB data generation and analysis tools, in order to optimize the manner in which donors and partners invest in and provide technical support to country TB programs. This project draws on CDC’s expertise in TB surveillance and program evaluation, as well as its strong partnerships with countries and global stakeholders. These stakeholders will provide input into this review, with a view to consolidating data collection and analytical methods for more efficient use. Findings will be synthesized into a framework that will be used to improve the efficiency of TB data generation globally and increase country use of TB data to prioritize resource allocation for effective program implementation.