To conduct research and analysis that will provide public health professionals, policy makers and legislators with an evidence-base to address gaps in care and service for Medicaid patients seeking STD care.

To evaluate the efficacy of a single, oral dose of zolifodacin in treatment of patients with uncomplicated gonorrhoea.

To explore the effectiveness of opt-out chlamydia screening via electronic health record prompt and to increase the percentage of women under the age of 25 who are screened for chlamydia at clinical encounters.

To learn lessons about how best to incorporate the delivery of daily oral pre-exposure prophylaxis (PrEP) into the services provided by health centers serving sexually active adults at high risk of acquiring HIV infection. The pilot study will initiate data collection at federally-qualified health centers (FQHCs) or look-alikes in four U.S. cities.