To facilitate formation of a Clinical Trials Unit for HIV/AIDS and tuberculosis research to advance therapy and prevention. If the interventions in the clinical trials are determined safe and effective, they will add to the options available to prevent and control these diseases of global significance.

To help CDC increase understanding of the effectiveness of using maternal tenofovir containing combination drug during the second and third trimesters of pregnancy for the prevention of mother-to-child transmission of HIV and HBV in co-infected mothers.

To perform Human Herpesvirus-8 (HHV-8) diagnostics on specimens from a UCSF study on antiretroviral therapy for patients with AIDS and Kaposi’s sarcoma in Uganda.

To conduct a study to assess the feasibility of a combination HIV preventive intervention with and without daily Truvada PrEP for HIV uninfected young men who have sex with men in Bangkok, Thailand.

To learn lessons about how best to incorporate the delivery of daily oral pre-exposure prophylaxis (PrEP) into the services provided by health centers serving sexually active adults at high risk of acquiring HIV infection. The pilot study will initiate data collection at federally-qualified health centers (FQHCs) or look-alikes in four U.S. cities.